
Hiccup Disease (しゃっくり病): The player drops random items at regular intervals.Invisibility (スケスケ病): The player disappears from the screen a number of times.Leisure Disease (のんびり病): The player's bombs take longer to explode.Hasty Disease (せっかち病): The player's bombs explode faster.Reverse Disease (リーバス病): The player's directional inputs on the controller are reversed.No Stop Disease (止まれん病): The player cannot stop moving.Lowest Disease (最低病): The player's explosions have minimum range.Inability Disease (不能病): The player cannot drop bombs.Diarrhea (下痢): The player drops bombs against his/her will.Slow-Footed Disease (鈍足病): The player moves very slowly.Fast Runner Disease (俊足病): The player moves at maximum speed.

The negative status can be removed by either passing it to another player (by walking into him/her) or by picking up another item. When picked up, a Skull gives the player a negative status effect. Some items are only available in the Normal Game or the Battle Game. The player reveals items by destroying Soft Blocks. Each one has a special ability that can be activated by holding the B button and pressing a direction on the D-pad. Summoned by Bagura, this quintet of evildoers are all playable in the Battle Game.

Only the Single Match may be played in this mode, and the first Battle Stage ( Usual) is the only one that is available. In this way, a handicap can be set for more experienced players, so that novice players may have a chance.

For a list of all of the Bonus Stages in this game, see the List of Bonus Stages in Super Bomberman 4. Many Bonus Stage Entrances appear in each stage, which lead to different Bonus Stages. Black Bomberman being controlled by player 2. In the Normal Game, the player must defeat all of the enemies on the map in order to open the Exit portal to the next stage. The two heroes are sent hurtling back in time, along with Blue, Red, Green, Orange, Aqua and Gold Bombermen, and Honey the cowgirl and Kotetsu the samurai, to fight through different eras, defeat the evil quintet and ultimately face Bagura. Bagura's brain escaped the explosion of his Battleship in Super Bomberman 3, and has summoned the Four Bomber Kings and Bomber Great to get revenge on White and Black Bomberman.
